孙青原，广东省第二人民医院首席科学顾问、生殖医学中心研究员。国家杰出青年基金获得者，“973”项目首席科学家，中国科学院“百人计划”入选者，新世纪百千万人才工程国家级人选，“十三五”生殖健康与重大出生缺陷重点研发计划专家组成员。

1994年获东北农业大学动物胚胎学理学博士学位。1996年-2001年先后在中国科学院动物研究所、以色列巴伊兰大学、美国密苏里大学、日本农业生物资源研究所等从事博士后或合作研究。1998年12月至2020年9月任中国科学院动物研究所研究员，中国科学院特聘研究员(核心骨干)，中国科学院大学岗位教授（首席教授）。历任计划生育生殖生物学国家重点实验室主任、中国动物学会副理事长、生殖生物学分会理事长、细胞及分子显微技术分会理事长、中国解剖学会发育生物学分会副主任委员、第六届国务院学位委员会生物学科评议组成员等。2020年10月调入广东省第二人民医院工作。

长期从事卵子发育、受精和早期胚胎发育的遗传和表观遗传调节研究，先后主持国家重大科学研究计划（973）项目、国家杰出青年基金项目、国家自然科学基金重点项目（3项）等30多个项目或课题。以（共同）通讯作者在Science、Nat Cell Biol、PNAS、Nat Comm、Nat Aging、Cell Death Differ、EHP、eLife、PLoS Genet、Development、JBC、JCS、FASEB J等杂志发表SCI论文440余篇，受邀为领域知名期刊如Hum Reprod Update、Mol Aspect Med、Autophagy、Semin Cell Develop Biol、Mol Endocinol、Mol Hum Reprod、Biol Reprod、JGG等撰写特邀综述或评论。主编参编中英文专著、译著和科普著作22部。连续7年入选爱思唯尔（Elsevier）中国高被引学者榜单（生化、遗传与分子生物学领域）。近5年来担任Biology of Reproduction、Molecular Human Reproduction、Journal of Genetics and Genomics、Molecular Reproduction and Development等16个SCI期刊副主编或编委和6个国内杂志的副主编和编委。

曾获全国优秀博士后、中国科学院青年科学家奖、中国科学院杰出青年、国家留学回国人员成就奖、中国青年科技奖、国家科技计划执行突出贡献奖等荣誉和国家自然科学二等奖1项、省部级一等奖4项、二等奖2项、全国妇幼健康科技奖自然科学一等奖等。

【最近3年发表的代表性论文】

Yue W, Wang Y, Meng TG, Zhang HY, Zhang XR, Ouyang YC, Hou Y, Schatten H, Wang ZB*, Sun QY*, Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation. FASEB J, 2022 (In press).

Su R#, Fan LH#, Cao C#, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL*, Sun QY*, Xue Y*. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021 Jun;23(6):664-675. doi: 10.1038/s41556-021-00696-9.

Zhu FZ#, Wang LL#, Meng  TG#, Wang RL#, Yang ZX#, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng  WT, Wang  ZB*, Sun  QY*, Zhang D*, Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice. Nat Aging 2021, 1 1010–1023.

Zhao ZH, Meng TG, Zhang HY, Hou Y, Schatten H, Wang ZB, Sun QY*. Single cell RNA sequencing reveals species-specific time spans of cell cycle transitions in early oogenesis. Hum Mol Genet. 2021 Feb 11:ddab048. doi: 10.1093/hmg/ddab048. Online ahead of print.

Chen LJ, Zhang NN, Zhou CX, Yang ZX, Li YR, Zhang T, Li CR, Wang X, Wang Y, Wang ZB, Xia ZR, Wang ZB, Zhang CL*, Guan YC*, Sun QY*, Zhang D*. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation.

Cell Death Differ. 2021 Oct 11. doi: 10.1038/s41418-021-00861-5.

Meng TG#, Zhou Q#, Ma XS#, Liu XY#, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH*, Wang ZB*, Gao SR*, Sun QY*. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Nat Commun. 2020 Dec 11;11(1):6354. doi: 10.1038/s41467-020-20242-9

Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB*, Sun QY*. Protein phosphatase 6 is a key factor regulating spermatogenesis. Cell Death Differ. 2020 Jun;27(6):1952-1964. 

Zhao ZH, Li CY, Meng TG, Wang Y, Liu WB, Li A, Cai YJ, Hou Y, Schatten H, Wang ZB, Sun QY*, Sun Q* Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis). .Cell Discov. 2020 Dec 29;6(1):97. doi: 10.1038/s41421-020-00219-0.

Zhao ZH, Ma JY, Meng TG, Wang ZB, Yue W, Zhou Q, Li S, Feng X, Hou Y, Schatten H, Ou XH*, Sun QY*. Single-cell RNA sequencing reveals the landscape of early female germ cell development. FASEB J. 2020 Jul 27. doi: 10.1096/fj.202001034RR. Online ahead of print.

Wang Y, Li J, Dong F, Yue W, Ouyang YC, Wang ZB, Hou Y, Schatten H, Sun QY*. CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes. J Cell Sci. 2020 Feb 10;133(3):jcs238105. doi: 10.1242/jcs.238105.

Zhou Q, Li J, Yue W, Li A, Meng TG, Lei WL, Fan LH, Ouyang YC, Schatten H, Wang ZB, Sun QY*. Cell division cycle 23 is required for mouse oocyte meiotic maturation. FASEB J. 2020 Jul;34(7):8990-9002. 

Yin Y, Cao S, Fu H, Fan X, Xiong J, Huang Q, Liu Y, Xie K, Meng TG, Liu Y, Tang D, Yang T, Dong B, Qi S, Nie L, Zhang H, Hu H, Xu W, Li F, Dai L, Sun QY, Li Z. A noncanonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22237-22248.

Han F, Dong MZ, Lei WL, Xu ZL, Gao F, Schatten H, Wang ZB, Sun XF*,Sun QY*. Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice. Mol Hum Reprod. 2020 Dec 30:gaaa083. doi: 10.1093/molehr/gaaa083. Online ahead of print.PMID: 33377946

Zhao ZH, Schatten H, Sun QY*. High throughput sequencing reveals landscapes of female germ cell development. Mol Hum Reprod. 2020 Aug 31:gaaa059. doi: 10.1093/molehr/gaaa059. Online ahead of print.

Du Z, Zheng H, Kawamura YK, Zhang K, Gassler J, Powell S, Xu Q, Lin Z, Xu K, Zhou Q, Ozonov EA, Véron N, Huang B, Li L, Yu G, Liu L, Au Yeung WK, Wang P, Chang L, Wang Q, He A, Sun Y, Na J, Sun Q, Sasaki H, Tachibana K, Peters AHFM, Xie W. Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Mol Cell. 2020 Feb 20;77(4):825-839.e7. doi: 10.1016/j.molcel.2019.11.011. 

Zhang P, Feng Y, Li L, Ge W, Yu S, Hao Y, Shen W, Han X, Ma D, Yin S, Tian Y, Min L, Sun Z, Sun Q, Zhang H, Zhao Y. Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice. Gut 2020 Apr 17:gutjnl-2020-320992. doi: 10.1136/gutjnl-2020-320992. Online ahead of print.

Huang L, Meng TG, Ma XS, Wang ZB, Qi ST, Chen Q, Zhang QH, Liang QX, Wang ZW, Hu MW, Guo L, Ouyang YC, Hou Y, Zhao Y, Sun QY*. Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice. Cell Death Differ. 2019 May;26(5):969-980.

Li J, Ouyang YC, Zhang CH, Qian WP*, Sun QY*. Cyclin B2-CDK1 inhibits separase activity in oocyte meiosis I. Development 2019 Dec 2;146(23). pii: dev182519. doi: 10.1242/dev.182519.

Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB*, Sun QY*. Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. 2019 Jan;33(1):1179-1187.

Ma JY, Yan LY, Wang ZB, Luo SM, Yeung WSB, Ou XH*, Sun QY*, Qiao J*. Meiotic chromatid recombination and segregation assessed with human single cell genome sequencing data. J Med Genet. 2019 Mar;56(3):156-163. doi: 10.1136/jmedgenet-2018-105612. Epub 2018 Dec 4.

Chen LJ, Yang ZX, Wang Y, Du L, Li YR, Zhang NN, Gao WY, Peng RR, Zhu FY, Wang LL, Li CR, Li JM, Wang FQ*, Sun QY*, Zhang D*. Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. Aging Cell. 2019 Aug 6:e13024. doi: 10.1111/acel.13024. [Epub ahead of print]